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Higher Birth Weight Linked to Higher Risk for Rheumatoid Arthritis in Adulthood 

According to the result of a study Infants with a birth weight of more than 4.54 kg have an increased risk for the development of rheumatoid arthritis (RA) as an adult. This study was conducted by L.A. Mandl and colleagues, from the Hospital for Special Surgery in New York.

This study was a prospective cohort study and its results have been reported in the June 30 Online First issue of the Annals of the Rheumatic Diseases.

L.A. Mandl says: We examine whether the fetal environment, as reflected by birth weight, could modulate an individual's future risk of RA. In this study, 87,077 women enrolled and observed prospectively, between 1976 and 2002.

The result of this study showed, there were 619 women who had new confirmed diagnoses of RA. In this study the potential confounders included a history of maternal diabetes, socioeconomic status in childhood, prematurity, and maternal and paternal smoking.

According to this report, compared with a birth weight 3.2 to 3.85 kg, a birth weight of more than 4.54 kg was associated with double the risk for RA in an age-adjusted model (relative risk [RR], 2.1; 95% confidence interval [CI], 1.4 - 3.3). This association was not affected by further adjustment for potential confounders and RA risk factors (RR, 2.0; 95% CI, 1.3 - 3.0). The investigators concluded birth weight > 4.54 kg was associated with a two-fold risk of adult onset RA, compared with those of average birth weight,

Resource: Medscape Pediatrics

© 2007 - Tehran, Iran, Department Of Pediatrics, Tehran University of Medical Science - RayanPajouh